Journal Reviews

CD40L activation of human RPE cells

1 August 2018 | | Retina / Uvea / Vitreous | AMD, Age-related macular degeneration, CD40L, IL-1β, Inflammasome, MCP-1, RPE, Retinal pigment epithelium

Age-related macular degeneration (AMD) is the leading cause of reduced visual acuity in the elderly worldwide. The risk factors involved in AMD include smoking and diet, while genetics have been shown to have a significant role. Recently a link between...

Transfected RPE cells inhibit AMD in rats

1 August 2015 | | Retina / Uvea / Vitreous | Age-related macular degeneration, Choroidal neovascularization, Fibulin-5, Retinal pigment epithelium, Transplantation

Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. Wet AMD is characterised by choroidal neovascularisation, new vessels into the retina, leading to leakage and tissue damage. Many proangiogenic factors particularly vascular endothelial growth factor (VEGF)...